Cut bread into large slices (about 3 inches wide) and arrange in a lightly sprayed 9x13 inch pan.
In a large bowl beat together eggs, milk, sugar, and vanilla. Pour mixture over bread slices. Arrange apples on top of bread.
Sprinkle cinnamon, nutmeg, and sugars (sprinkle the brown sugar the most generously) over the apples.
Cover and refrigerate at least an hour and up to 24 hours.
In the morning bake for 1 hour at 350 until golden brown.
Top with your favorite caramel topping. Mrs. Richardson's Butterscotch Caramel is our favorite but even better than that is making it from bagged caramels: 1 pkg wrapped caramels and 2/3 cup whipping cream. Melt together in microwave.
Video
Notes
How to Make this French Toast Ahead
The night before, place it in a baking dish. Cover with plastic wrap or foil. Place in the refrigerator overnight, then bake in the oven the next morning.