In a large bowl, mix together flour, sugar, baking soda, and salt.
In a separate bowl, whisk together the egg, buttermilk, and vanilla.
Add the wet ingredients to the dry ingredients and stir until combined.
Heat a griddle to medium heat and spray with cooking spray.
Pour 1/4 cup of pancake mixture onto the griddle.
Once the sides start to dry and the top is bubbling, flip the pancake using a large spatula.
Cook until both sides of the pancake are golden brown and the middle is cooked through (you can check by inserting a toothpick into the middle of the pancake - if it comes out dry it is done).
Remove from heat and serve with your favorite pancake topping.